人才队伍

复旦大学智能医学研究院，副研究员

个人简介：

张文，复旦大学上海医学院副教授/副研究员，华中科技大学研究生，复旦生科院博士，曾在中科院生化细胞所和加州大学伯克利分校学习与工作。从事核糖体翻译研究多年，进行结构解析、计算和转化医学应用。研究过多个核糖体与抗生素结构、HLA免疫相关疾病的分子机制和精子畸形的结构机制。共发表30多篇文章，引用3000 多次，其中第一作者和通讯作者在《Science》、《Nature Struct Mol Biol》、《EMI》等发表，获973、国家自然科学基金和部委专项等多个项目基金，参与申请并获得国际专利一项。

研究方向：

1. Ribosome structure and dynamics during translation elongation

2. Ribosome-antibiotics complex and drug resistance mechanism

代表性论文：

1. Y Ruan, L Sun, Y Hao, L Wang, J Xu, W Zhang,et al. Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma. J Clin Invest. 2012; 122:2554–2566 (initial data for crystallography. )

2. Beatriz LS, Dunkle J, Dorota L, Zhang W, Fernandes P, Cate J, Alexander M. Binding and action of CEM-101, a new fluor oketolide antibiotic that inhibits protein synthesis. Antimicrobial Agents and Chemotherapy. 2010, Vol. 54: 4961-4970

3. Zhang W*, Dunkle J, Cate J. Structures of the ribosome in intermediate states of ratcheting. Science 325, 1014 (2009). True milestone work comments by Liljas Anders. Leaps in Translational Elongation. Science 326, 677-678

4. Pai RD*, Zhang W*, Schuwirth BS, Hirokawa G, Kaji H, Kaji A, Cate JHD. Structural Insights into Ribosome Recycling Factor Interactions with the 70S Ribosome. J Mol Biol. 2008 7; 376(5):1334-47. *Equal contribution  

5. Borovinskaya MA*, Pai RD*, Zhang W*, Schuwirth BS, Holton JM, Hirokawa G, Kaji H, Kaji A, Cate JH. Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nature Struct Mol Biol. 2007 Aug; 14(8):727-32.  (Important Progress cited by APS 2007 annual report ) *Equal contribution

6. Berk V, Zhang W, Pai RD, Cate JH. Structural basis for mRNA and tRNA positioning on the ribosome. Proc Natl Acad Sci USA. 2006 Oct 24; 103(43): 15830-4

7. Schuwirth BS, Borovinskaya MA, Hau CW, Zhang W, Sanjurjo AV, Holton JM , Cate JHD, Structures of the bacterial ribosome at 3.5 Å resolution. Science 2005 4; 310: 827-34    

8. Anton VS, Ridgeway W, Seymaner V, Zhang W, Santoso S, Yu K，Cate JHD. X-ray crystal structures of the WT and a hyper-accurate ribosome from Escherichia coli. Proc Natl Acad Sci USA 100(15) P8682