师资力量

研究方向：AI赋能的神经退行性疾病药物发现

科研工作经历：

2025 至 今, 复旦大学智能医学研究院，青年研究员

2023 至 今, 复旦大学长寿与衰老研究所（院），办公室主任

2023 至 今, 复旦大学附属中山医院, 青年研究员

2020 至 2022, 清华大学, 博士后/助理研究员

2010 至 2012, 英国最大药企葛兰素史克研发部, 科学家

发表的代表性论著：（*第一作者，#通讯作者）

(1) Pang, K*., Jiang R., Zhang W., Yang Z., Li LL., Shimozawa M., Tambaro S., Mayer J., Zhang B., Li M., Wang J., Liu H., Yang A., Chen X., Liu J., Winblad B., Han H., Jiang T., Wang W., Nilsson P., Guo W., Lu B. An App knock-in rat model for Alzheimer's disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments. Cell Res 32(2):157-175 2022

(2) Wang X*., Pang K*., Li J., Wang Y., Chu T., Yang J., Lu B., Wu S., Zheng C., Ming D. A retrospective attractor of hippocampal CA1 representation during novelty encoding in an App knock-in rat model of Alzheimer's disease. (Under review in Nature Aging) (2025)

(3) Han X*., Pang KL*., Liu X., Zhou J., Zhu J., and Yuan H. Novel roles for CREG1 in hematopoiesis revealed by single cell RNA sequencing.Cell and Bioscience (2025).

(4) Guo, W*., Pang, K*., Chen, Y., Wang, S., Li, H., Xu, Y., Han, F., Yao, H., Liu, H., Lopes-Rodrigues, V., Sun D., Shao J., Shen J., Dou Y., Zhang W., You H., Wu W., Lu B. TrkB agonistic antibodies superior to BDNF: Utility in treating motoneuron degeneration. Neurobiology of Disease 132, 104590 2019（获批进入临床）

(5) Pang, K*., You, H., Chen, Y., Chu, P., Hu, M., Shen, J., Guo, W., Xie, C., and Lu, B. MagR Alone Is Insufficient to Confer Cellular Calcium Responses to Magnetic Stimulation. Front Neural Circuits 11, 11 2017 Nature News 报道

(6) Chen ZY., Zheng WJ., Pang, K#., Xia DB., Gao LX., Wang H#. Weakly-supervised learning analysis of Aβ plaque distribution in whole rat. Frontiers in Neuroscience (2023).

(7) Jiang Y*., Li LL*., Pang, K*., Liu J., Chen B., Yuan J., Chen Xi., Lu B and Han H. Synaptic degeneration in the prefrontal cortex of a rat AD model revealed by volume electron microscopy. Journal of Molecular Cell Biology 012 2022

(8) Zhuo L, Pang K, Dai J, Wu B, Wang J, Xu H, Yang S, Liu Z, Niu R, Yu P, Wang W. The neurophysiological mechanisms of medial prefrontal-perirhinal cortex circuit mediating temporal order memory decline in early stage of AD rats. Neurobiology of Disease 199:106584 (2024).

(9) Chang, S., Li, LL., Hong, B., Liu, J., Xu, YX., Pang, K., Zhang, LN., Han, H., Chen, X. An intelligent workflow for sub-nanoscale 3D reconstruction of intact synapses from serial section electron tomography. Bmc Biology 21(1):198 (2023).

(10) Wang, TW., Gong, J., Wang, Y., Liang, Z., Pang, K., Wang, JS., Zhang, ZH., Zhang, CY., Zhou, Y., Li, JC., Wang, YN., Zhou, YJ. Differences in Non-suicidal Self-injury Behaviors between Unipolar Depression and Bipolar Depression in Adolescent Outpatients.Current Medical Science 10.1007 (2023).

(11) Shen, J., Sun, D., Shao, J., Chen, Y., Pang, K., Guo, W., and Lu, B. Extracellular Juxtamembrane Motif Critical for TrkB Preformed Dimer and Activation. Cells. 19; 8(8):932 2019

(12) Huang, Y., Huang, X., Zhang, L., Han, F., Pang, K., Li, X., and Shen, J.Y. Magnesium boosts the memory restorative effect of environmental enrichment in Alzheimer's disease mice. CNS Neurosciecne & Therapeutics 24, 70-79 2018