人才队伍

单位

复旦大学，智能医学研究院

教育经历

· 2006/09-2009/07，上海大学,生物电子中心，电子生物，博士。

· 2003/09-2006/03，上海大学,生物电子中心，计算软件与理论，硕士。

· 1996/09-2002/07，浙江大学，医学院，临床医学专业毕业，学士。

国外学习经历

· 2015/09-2017/02，哈佛大学Dana-Farber研究所，访问学者(国家公派)。

· 2009/11-2010/01，美国加州圣地亚哥分校/NIH/哈佛大学，访问学者。

工作经历

· 2021/01-至今，复旦大学生物医学研究院，研究员。

· 2013/01-2020/12，复旦大学生物医学研究院，副研究员。

· 2009/09-2012/12，复旦大学生物医学研究院，助理研究员。

研究简介

主要从事表观遗传学和生物信息学前沿基础科学研究，并取得了一系列重要研究成果。2011年率先报道了小鼠胚胎干细胞中TET1蛋白调控DNA羟甲基化的分子机制；2012年明确了黑色素瘤中DNA甲基化和羟甲基化的变化特征，明确了DNA羟甲基化信号变化与黑色素瘤的关系；最近，报道NONO蛋白与TET1相互作用，影响小鼠胚胎干细胞向神经细胞分化；揭示了阿尔茨海默病神经细胞模型和脑组织的DNA甲基化和羟甲基化的基因组分布特征，及评估其在判断阿尔茨海默病发生中的作用；发明了一种全新DNA甲基化检测方法，该方法在一次实验中可以同时检测DNA突变和DNA甲基化，可用于精准检测遗传改变和表观遗传改变，该方法已获得了中国和美国专利授权。此外，还研究了CD151及其复合体信号网络在肝癌发生发展中的作用机制。发表高水平SCI论文40余篇，谷歌学术指数（H-index）为23，文章累计引用次数达4196次。研究项目获得国家“863”、国家重大研究计划、国家自然科学基金面上项目，以及上海市自然科学基金面上项目等资助。

论文发表

在Cell、Nature、Science Advances、Nucleic Acids Research、Molecular Cell、Hepatology等高水平杂志发表SCI论文40余篇。以共同第一作者或者共同通讯作者署名论文10篇，其中6篇SCI影响因子（IF）>10, 其它署名文章15篇。目前谷歌学术指数（H-index）为23，文章累计引用超过4000次，其中引用超过600次的论文2篇，超过100次的论文13篇。

通讯作者或第一作者署名的文章

1. Xiaoqiang Chai, Jianfei Guo, Ruizhao Dong, Xuan Yang, Chao Deng, Chuanyuan Wei, JiaJie Xu, Weiyu Han, Jiacheng Lu, Chao Gao, Dongmei Gao, Cheng Huang, Aiwu Ke, Shuangqi Li, Huanping Li, Yingming Tian, Zhongkai Gu, Shuxian Liu, Hang Liu, Qilong Chen, Feng Liu, Jian Zhou, Jia Fan, Guoming Shi,Feizhen Wu^#, Jiabin Cai^#. Quantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B‐related hepatocellular carcinoma.Clinical and translational medicine, 2021; 11(3) (#共同通讯作者，IF7.8)

2. Dingailu Ma, Irfete S Fetahu, Mei Wang, Rui Fang, Jiahui Li, Hang Liu, Tobin Gramyk, Isabella Iwanicki, Sophie Gu, Winnie Xu, Li Tan,Feizhen Wu^#, Yujiang G Shi^#. The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease.Clinical Epigenetics, 27 August 2020(#共同通讯作者，IF5.028)

3. Shuangqi Li*, Jiuxing Feng*,Feizhen Wu*^#, Jiabin Cai, Xinyu Zhang, Haikun Wang, Irfete S Fetahu, Isabella Iwanicki, Dingailu Ma, Tao Hu, Hang Liu, Bingjie Wang, Guoming Shi^#, Li Tan^#, Yujiang Geno Shi^#.TET2 promotes anti‐tumor immunity by governing G‐MDSCs and CD8+ T‐cell numbers.EMBO reports, 2020 (#共同一作且共同通讯作者，IF7.497)

4. Wenjing Li^*, Violetta Karwacki-Neisius^*#, Chun Ma, Li Tan, Yang Shi,Feizhen Wu^#and Yujiang Geno Shi^#. Nono deficiency compromises TET1 chromatin association and impedes neuronal differentiation of mouse embryonic stem cells.Nucleic Acids Research, 2020 (#共同通讯作者，IF11.501)

5. Irfete S Fetahu, Dingailu Ma, Kimberlie Rabidou, Christian Argueta, Michael Smith, Hang Liu,Feizhen Wu^#,Yujiang G Shi^#. Epigenetic signatures of methylated DNA cytosine in Alzheimer’s disease. Science Advances2019; 5(8) (#共同通讯作者，IF13.116)

6. Jin Li, Yan Li, Wei Li, Huaibing Luo, Yanping Xi, Shihua Dong, Gao M,Xu P,Zhang B,Liang Y,Zou Q,Hu X,Peng L,Zou D,Wang T,Yang H,Jiang C, Peng SL^#,Wu Feizhen^#，Yu WQ^#. Guide Positioning Sequencing identifies aberrant DNA methylation patterns that alter cell identity and tumor-immune surveillance networks.Genome Research.2019; 1(22) (#共同通讯作者，IF 11.093)

7. Wenqi Xu^†, Jiahui Li^†, Bowen Rong, Hongjie Shen, Bin Zhao, Mei Wang, Qilong Chen, Hang Liu, Zhongkai Gu, Shuxian Liu, Rui Guo,Feizhen Wu^#, Fei Lan^#. DNMT3A Reads and Connects Histone H3K36me2 to DNA methylation.Protein & Cell.2020 Feb;11(2):150-154 (#共同通讯作者，IF 10.164)

8.Peng L,Li Y,Xi Y,Li W,Li J, Lv R, Zhang L,Zou Q, Dong S,Luo H,Wu Feizhen^#,Yu W^#. Methyl-CpG-binding domain protein 3-like 2 (MBD3L2) promotes Tet2 enzymatic activity for mediating 5mC oxidation.J Cell Sci2016 Jan 14. (#共同通讯作者,IF 4.7)

9. Xu Y*,Wu Feizhen*, Tan L*, Kong L, Xiong L, Deng J, Barbera AJ, Zheng L, Zhang H, Huang S, Min J, Nicholson T, Chen T, Xu G, Shi Y, et al.Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells.Molecullar Cell2011;42(4):451-464. (*共同第一作者, IF15.584)

10. Ke AW*, Shi GM*, Zhou J*,Wu Feizhen*, Ding ZB, Hu MY, Xu Y, Song ZJ, Wang ZJ, Wu JC, Bai DS, Li JC, Liu KD, Fan J. Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma.Hepatology2009;49(2):491-503.(*共同第一作者,IF 14.679)

11. Devbhandari RP*, Shi GM*, Ke AW*,Wu Feizhen*, Huang XY, Wang XY, Shi YH, Ding ZB, Xu Y, Dai Z, Fan J, Zhou J. Profiling of the tetraspanin CD151 web and conspiracy of CD151/integrin beta1 complex in the progression of hepatocellular carcinoma.PLoS One2011;6(9):e24901. (*共同第一作者,IF 4.092)

部分其它署名的文章

12. Wenqi Xu, Jiahui Li, Chenxi He, Jing Wen, Honghui Ma, Bowen Rong, Jianbo Diao, Liyong Wang, Jiahua Wang,Feizhen Wu, Li Tan, Yujiang Geno Shi, Yang Shi, Hongjie Shen. METTL3 regulates heterochromatin in mouse embryonic stem cells.Nature2021.

13. Yangliu Song, Weicheng Chen, Zitong Huang, Guixiang Tian, Mengru Li, Zhengshan Zhao, Zhiyu Feng, Feizhen Wu, Maoxiang Qian, Xiaojing Ma, Wei Sheng, Guoying Huang. A Non-coding HES1 Variant Predisposes Children to Congenital Heart Disease in Chinese Population.Frontiers in cell and developmental biology. 2021.

14. Wu, D., Hu, D., Chen, H., Shi, G., Fetahu, I. S.,Wu Feizhen, Rabidou, K., Fang, R., …, Lan, F., Fan, J., Shi, Y., Shi, Y. G. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer.Nature. 2018 Jul (IF 41.57)

15. Ying Wang, Chao Yin, Zhidan Chen, Yang Li, Yan Zou, Xiang Wang, Yanpeng An,Feizhen Wu, Guoping Zhang, Chunjie Yang, Huiru Tang, Yunzeng Zou, Hui Gong. Cardiac-specific LRP6 knockout induces lipid accumulation through Drp1/CPT1b pathway in adult mice.Cell and tissue research.2019

16. Lian CG, Xu Y, Ceol C,Wu Feizhen, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, et al.Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma.Cell2012;150(6):1135-1146. (IF 31.957)

17. Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J,Wu Feizhen, He HH, Cui Q, Clark E, et al.Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development.Cell2012;151(6):1200-1213. (IF 31.957)

18. Dango S, Mosammaparast N, Sowa ME, Xiong LJ,Wu Feizhen, Park K, Rubin M, Gygi S, Harper JW, Shi Y. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.Mol Cell2011;44(3):373-384. (IF 14.178)

19. Chen T, Huang Z, Wang L, Wang Y,Wu Feizhen, Meng S, Wang C. MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages.Cardiovasc Res. 2009;83(1):131-139. (IF 5.8)

20. Rajakumara E, Wang Z, Ma H, Hu L, Chen H, Lin Y, Guo R,Wu Feizhen, Li H, Lan F, Shi YG, Xu Y, Patel DJ, Shi Y. PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression.Mol Cell2011;43(2):275-284. (IF 14.178)

21. Chen S, Ma J,Wu Feizhen, Xiong LJ, Ma H, Xu W, Lv R, Li X, Villen J, Gygi SP, Liu XS, Shi Y. The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.Genes Dev2012;26(12):1364-1375. (IF 12.64)

22. Tan L, Xiong L, Xu W,Wu Feizhen, Huang N, Xu Y, Kong L, Zheng L, Schwartz L, Shi Y, Shi YG. Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method.Nucleic Acids Res2013;41(7):e84. (IF 10.16)

23. Q. Gao, Y. J. Zhao, X. Y. Wang, W. J. Guo, S. Gao, L. Wei, J. Y. Shi, G. M. Shi, Z. C. Wang, Y. N. Zhang, Y. H. Shi, J. Ding, Z. B. Ding, A. W. Ke, Z. Dai,Wu Feizhen, H. Wang, Z. P. Qiu, Z. A. Chen, Z. F. Zhang, S. J. Qiu, J. Zhou, X. H. He and J. Fan.Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients.Gastroenterology2014;146(5):1397-1407. (IF 18.39)

24. Guo R, Zheng L, Park JW, Lv R, Chen H, Jiao F, Xu W, Mu S, Wen H, Qiu J, Wang Z, Yang P,Wu Feizhen, Hui J, Fu X, et al.BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing.Mol Cell2014;56(2):298-310. (IF 14.178)

25. Laurent B, Ruitu L, Murn J, Hempel K, Ferrao R, Xiang Y, Liu S, Garcia BA, Wu H,Wu Feizhen, Steen H, Shi Y. A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation.Mol Cell2015;57(6):957-970 (IF 14.178)

26. Chun Ma, Violetta Karwacki-Neisius, Haoran Tang, Wenjing Li, Zhennan Shi, Haolin Hu, Wenqi Xu, Zhentian Wang, Lingchun Kong, Ruitu Lv, Zheng Fan, Wenhao Zhou, Pengyuan Yang,Wu Feizhen, Jianbo Diao, Li Tan, Yujiang Geno Shi, Fei Lan, Yang Shi.Nono, a bivalent domain factor, regulates Erk signaling and mouse embryonic stem cell pluripotency.Cell reports2016;17(4): 997-1007 (IF8.28)

27. Xiao M, Li J, Li W, Wang Y,Wu Feizhen, Xi Y, Zhang L, Ding C, Luo H, Li Y, Peng L, Zhao L, Peng S, Xiao Y, Dong S, Cao J, Yu W. MicroRNAs activate gene transcription epigenetically as an enhancer trigger.RNA Biol.2016 Feb 6:1-9. (IF3.9)

28.Shen H,Xu W,Guo R,Rong B,Gu L,Wang Z,He C,Zheng L,Hu X,Hu Z,Shao ZM,Yang P,Wu Feizhen,Shi YG,Shi Y,Lan F. Suppression of Enhancer Overactivation by a RACK7 Histone Demethylase Complex.Cell.2016 Apr 7;165(2):331-42. (IF 31.957)

29. Kong L, Tan L, Lv R, Shi Z, Xiong L,Wu Feizhen, Rabidou K, Smith M, He C, Zhang L, Qian Y, Ma D, Lan F, Shi Y, Shi YG. A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands.Nucleic Acids Res.2016 Oct 14;44(18):8682-8692. (IF 10.16)